Dr. Vinila Reddy
MBBS MD(Pathology)3 min read



Sickle cell disease is a phenomenon where the red blood cells take the shape of a sickle or a crescent moon. It makes it difficult for these cells to move around easily through the blood vessels. This slows down or could even block the adequate flow of oxygen and blood to the different parts of the body causing health problems.
Haemoglobin is a tetrameric protein composed of two pairs of globin chains each with a heme group.
In sickle cell disease or sickle cell anaemia, there is a point mutation of the beta-globin chain, thus impacting in replacement of glutamic acid to valine residue in the beta-globin which causes sickling of the RBC. The type of haemoglobin responsible for sickle cell disease is HbS. It leads to micro- vasculature obstruction and tissue damage.
Sickle cell disease affects millions of people globally. The most common ways to treat this disease is through blood transfusions and bone marrow transplant.
Sickle cell disease is an inherited disorder causing red blood cell distortion, destruction. The inheritance is homozygous for sickle cell disease if transferred from both the parents.
If inheritance from one parent impacts in the milder form, it is called sickle cell trait (Hb AS). The HbSS molecules (RBC) build up into polymers when deoxygenated, yet giving rise to chronic haemodialysis, microvascular occlusions at the same time tissue damage.
During deoxygenation, the cytoplasm in red blood cell/RBC turns from free-flowing liquid into viscous gel and assemble themselves into long needle-like fibres within RBC and produce a sickle shape.
Young patients will show signs of the following:
Signup for weekly newsletter
By clicking, you agree to T&C and Privacy policy
Copyright Lifetime Wellness Rx International Limited. All rights reserved throughout India.
Reproduction in part or in whole is prohibited. Wellness suggestions and treatments discussed in this issue are only indicators of what makes one healthy or not. It may not be an accurate assessment of what’s specifically ideal for you. Consult with your doctor before undertaking any treatment.
Copyright @ 2020 UR Life
We will credit the consultation fees if you choose to take one or more sessions
Book NowWe will credit the consultation fees if you choose to take one or more sessions
Book NowPlease select mood!
Get unlimited access to personalised wellness content curated by Upasana
Share your feedback to make UR wellness journey even better
Your first step to wellness, in less than a minute.
Minimum of 8 characters with atleast one number
Get unlimited access to personalised wellness content curated by Upasana